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Brand Name: Arava Generic name: Leflunomide
Category:  Anti-Inflammatory Preparation: Tablet, Capsule
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Arava (leflunomide) is used to reduce inflammation and swelling due to rheumatoid arthritis.

Arava helps to treat all stages of adult rheumatoid arthritis.

Arava works by stopping the body from producing too many of the immune cells that are responsible for the swelling and inflammation.

Arava can be used with some of the other medications that are used to treat the inflammation and pain of this condition (for example, aspirin, other salicylates, or nonsteroidal anti-inflammatory drugs like ibuprofen).

Arava is an oral, disease-modifying drug used to treat rheumatoid arthritis. Arava reduces inflammation in the joints that is responsible for both the symptoms of rheumatoid arthritis and the destruction of joints. This reduces symptoms as well as the progressive deformities of the joints caused by the arthritis. Arava reduces inflammation by suppressing the activity of immune cells responsible for the inflammation. Arava suppresses immune cells by inhibiting dihydroorotate dehydrogenase, an enzyme that is necessary for the production of DNA and RNA. Without DNA and RNA the immune cells (and most other types of cells) cannot multiply or function. Because of its unique and different mechanism of action, Arava is of value when added to other medications used for treating rheumatoid arthritis.

Most Important Fact about Arava: Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop taking Arava except on your prescriber's advice.

Arava precautions if you are pregnant or breastfeeding: Arava must not be taken during pregnancy because it may cause birth defects in the developing baby. If you are still in your childbearing years, your doctor will want to see negative results from a pregnancy test before starting you on Arava. You'll also need to use reliable contraceptive measures as long as you take Arava.

If you become pregnant while taking Arava, your doctor will stop Arava immediately and prescribe a regimen of cholestyramine (Questran) in 8-gram doses 3 times a day for 11 days. Questran helps to clear Arava from the bloodstream, possibly preventing harm to the unborn child.

It is not known whether Arava passes into the breast milk. However, Arava is not recommended during breast-feeding, because it may cause unwanted effects in nursing babies.

Special warnings about Arava
Visit your prescriber or health care professional for checks on your progress. You will need to have regular blood checks and tests to see if your liver is working properly. The side effects of Arava can continue after you finish your treatment; report side effects promptly.

While you are taking Arava you might be more susceptible to infection. Try to avoid people with colds, flu, and bronchitis. Do not have any vaccinations without your doctor's approval.

Call your health care professional for advice if you get a fever, chills or sore throat, do not treat yourself.

If you are going to have surgery tell your doctor or dentist that you are taking Arava.

Alcoholic drinks can make you more dizzy and increase possible damage to your liver. Avoid alcoholic drinks while taking Arava.

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